Cancers | Free Full-Text | Ibrutinib Associated with Rituximab-Platinum Salt-Based Immunochemotherapy in B-Cell Lymphomas: Results of a Phase 1b-II Study of the LYSA Group
Flexibility of the BLRM in Dose-Escalation Trials
Dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) in Phase... | Download Table
Single-arm, open-label, dose-escalation phase I study to evaluate the safety of a herbal medicine SH003 in patients with solid cancer: a study protocol. - Abstract - Europe PMC
Exposure driven dose escalation design with overdose control: Concept and first real life experience in an oncology phase I trial - ScienceDirect
Entropy | Free Full-Text | Escalation with Overdose Control is More Efficient and Safer than Accelerated Titration for Dose Finding
1. In a typical Phase I clinical trial of a new drug, | Chegg.com
Illustration of the chronic dose-limiting toxicity (DLT) concept. (*)... | Download Scientific Diagram
A Bayesian Logistic Model with Covariate to Identify Optimal Dose for Heterogeneous Population in Phase I Oncology Trial Xin Wei, Mike Branson Celgene. - ppt download
Recommended dosages in each arm. DLT, dose-limiting toxicity; RD,... | Download Scientific Diagram
BOIN Suite: A Software Platform to Design and Implement Novel Early-Phase Clinical Trials | JCO Clinical Cancer Informatics
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
A Multicenter Phase I/II Study of Obatoclax Mesylate Administered as a 3- or 24-Hour Infusion in Older Patients with Previously Untreated Acute Myeloid Leukemia | PLOS ONE
DURVIT': a phase-I trial of single low-dose durvalumab (Medi4736) IntraTumourally injected in cervical cancer: safety, toxicity and effect on the primary tumour- and lymph node microenvironment | BMC Cancer | Full Text
Early phase clinical trials to identify optimal dosing and safety - Cook - 2015 - Molecular Oncology - Wiley Online Library
Study Design. DLT-dose limiting toxicity; MTD-maximum tolerated dose | Download Scientific Diagram
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study. - Abstract - Europe PMC
Dose Limiting Toxicities (DLT) DOSE LIMITING TOXICITIES (DLT) Example: Dose escalation will proceed within each cohort according
Study design. PK, pharmacokinetics; DLT, dose- limiting toxicity | Download Scientific Diagram
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study - ScienceDirect
